期刊
TRENDS IN PARASITOLOGY
卷 24, 期 1, 页码 29-34出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2007.10.004
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Plasmodium vivax requires interaction with the Duffy antigen receptor for chemokines (DARC) to enable its invasion of human erythrocytes. Interaction with DARC is mediated by the P. vivax Duffy-binding protein (PvDBP) and is essential for junction formation, which is a key step in the invasion process. The receptor-binding domain of PvDBP maps to a conserved cysteine-rich region, referred to as region II (PvRII). Here, we review data on the interaction of PvRII with DARC and explore the potential of targeting this crucial receptor-ligand interaction to develop new intervention strategies against P. vivax.
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