期刊
TRENDS IN NEUROSCIENCES
卷 37, 期 1, 页码 47-53出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2013.10.007
关键词
infantile amnesia; memory; engram; forgetting; molecular mechanisms
资金
- Australian Research Council [DP120104925]
- National Health and Medical Research Council [APP1031688]
Revealing the engram is one of the greatest challenges in neuroscience. Many researchers focus on understanding the cellular and molecular mechanisms underlying the formation and maintenance of the engram, but an under-utilized approach has been to investigate analogous processes associated with forgetting. Infant rodents present an ideal model for this purpose because they display a rapid form of non-pathological forgetting known as infantile amnesia (IA). Despite the widespread importance of this interesting phenomenon, the study of the neural bases of IA has remained largely neglected. Here, we consider what IA can tell us about memory. We argue that to understand the mechanisms underlying the engram we must also gain an appreciation of the mechanisms that drive forgetting.
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