期刊
TRENDS IN NEUROSCIENCES
卷 37, 期 9, 页码 502-510出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2014.06.003
关键词
auditory cortex; frequency; homogeneity; maps; heterogeneity; layers; electrophysiology; imaging; calcium; resolution; scale
资金
- National Institutes of Health (NIH) [R01DC009607, R01DC009836]
- Israel Science Foundation (ISF)
- US Israel Binational Science Foundation (BSF)
- European Research Council (ERC) [RATLAND-340063]
Topographic organization is a hallmark of sensory cortical organization. Topography is robust at spatial scales ranging from hundreds of microns to centimeters, but can dissolve at the level of neighboring neurons or subcellular compartments within a neuron. This dichotomous spatial organization is especially pronounced in the mouse auditory cortex, where an orderly tonotopic map can arise from heterogeneous frequency tuning between local neurons. Here, we address a debate surrounding the robustness of tonotopic organization in the auditory cortex that has persisted in some form for over 40 years. Drawing from various cortical areas, cortical layers, recording methodologies, and species, we describe how auditory cortical circuitry can simultaneously support a globally systematic, yet locally heterogeneous representation of this fundamental sound property.
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