期刊
TRENDS IN NEUROSCIENCES
卷 36, 期 3, 页码 195-206出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2012.11.002
关键词
mu opioid receptor; delta opioid receptor; kappa opioid receptor; mood; depression
资金
- CNRS
- INSERM
- Universite de Strasbourg
- Mouse Clinical Institute (ICS, Illkirch, France)
- European Union [GENADDICT/FP6 005166]
- Fondation pour la Recherche Medicale
- Fondation Fyssen
- National Institutes of Health (National Institute of Drug Addiction) [05010]
- National Institutes of Health (National Institute on Alcohol Abuse and Alcoholism) [16658]
The roles of opioid receptors in pain and addiction have been extensively studied, but their function in mood disorders has received less attention. Accumulating evidence from animal research reveals that mu, delta and kappa opioid receptors (MORs, DORs and KORs, respectively) exert highly distinct controls over mood-related processes. DOR agonists and KOR antagonists have promising antidepressant potential, whereas the risk benefit ratio of currently available MOR agonists as antidepressants remains difficult to evaluate, in addition to their inherent abuse liability. To date, both human and animal studies have mainly examined MORs in the etiology of depressive disorders, and future studies will address DOR and KOR function in established and emerging neurobiological aspects of depression, including neurogenesis, neurodevelopment, and social behaviors.
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