期刊
TRENDS IN NEUROSCIENCES
卷 36, 期 10, 页码 587-597出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2013.07.001
关键词
glucose metabolism; metabolic coupling; apoptosis; brain-body axis; metabolic brain disease
资金
- European Union [201024, 202213]
- Deutsche Forschungsgemeinschaft [Exc 257, Exc 1010]
- Bundesministerium far Bildung und Forschung (Center for Stroke Research Berlin_ [01 EO 08 01]
- Canadian Stroke Network European Stroke Network Transatlantic Collaboration grant
- National Institutes of Health [DK081936]
The mammalian brain depends upon glucose as its main source of energy, and tight regulation of glucose metabolism is critical for brain physiology. Consistent with its critical role for physiological brain function, disruption of normal glucose metabolism as well as its interdependence with cell death pathways forms the pathophysiological basis for many brain disorders. Here, we review recent advances in understanding how glucose metabolism sustains basic brain physiology. We synthesize these findings to form a comprehensive picture of the cooperation required between different systems and cell types, and the specific breakdowns in this cooperation that lead to disease.
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