Emerging role for astroglial networks in information processing: from synapse to behavior

Astrocytes contribute to neurotransmission through a variety of mechanisms ranging from synapse isolation to active signaling. Astroglial involvement in neurophysiology has been mostly investigated at the single-cell level. However, a unique feature of astrocytes is their high level of intercellular connectivity mediated by connexins, the proteins forming gap junction (GJ) channels. These astroglial GJ circuits enable the rapid intercellular exchange of ions, metabolites, and neuroactive substances. Recent findings have suggested that, despite their extensity, astroglial networks are also selective, preferential as well as plastic, and can regulate synapses, neuronal circuits, and behavior. The present review critically discusses the impact of astroglial networks on normal and pathological neuronal information processing as well as the underlying mechanisms.