期刊
TRENDS IN NEUROSCIENCES
卷 36, 期 11, 页码 621-631出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2013.08.002
关键词
early-life stress; epigenetics; programming; nutrients; hippocampus
资金
- Hersenstichting Nederland and ISAO: Internationale Stichting Alzheimer Onderzoek
Early-life stress lastingly affects adult cognition and increases vulnerability to psychopathology, but the underlying mechanisms remain elusive. In this Opinion article, we propose that early nutritional input together with stress hormones and sensory stimuli from the mother during the perinatal period act synergistically to program the adult brain, possibly via epigenetic mechanisms. We hypothesize that stress during gestation or lactation affects the intake of macro- and micro-nutrients, including dietary methyl donors, and/or impairs the dam's metabolism, thereby altering nutrient composition and intake by the offspring. In turn, this may persistently modulate gene expression via epigenetic programming, thus altering hippocampal structure and cognition. Understanding how the combination of stress, nutrition, and epigenetics shapes the adult brain is essential for effective therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据