期刊
TRENDS IN NEUROSCIENCES
卷 36, 期 5, 页码 305-312出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2013.01.005
关键词
microbiota; behavior; anxiety; gut-brain axis; germ-free; stress
资金
- National Science and Engineering Research Council of Canada (NSERC)
- Canadian Foundation for Innovation
- Ontario Graduate Scholarship
- Ontario Graduate Scholarship in Science and Technology
Within the first few days of life, humans are colonized by commensal intestinal microbiota. Here, we review recent findings showing that microbiota are important in normal healthy brain function. We also discuss the relation between stress and microbiota, and how alterations in microbiota influence stress-related behaviors. New studies show that bacteria, including commensal, probiotic, and pathogenic bacteria, in the gastrointestinal (GI) tract can activate neural pathways and central nervous system (CNS) signaling systems. Ongoing and future animal and clinical studies aimed at understanding the microbiota-gut-brain axis may provide novel approaches for prevention and treatment of mental illness, including anxiety and depression.
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