期刊
TRENDS IN NEUROSCIENCES
卷 36, 期 9, 页码 513-521出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2013.06.001
关键词
mast cells; neuroimmune interactions; psychiatric disease; multiple sclerosis; ischemia; NGF
Mast cells (MCs) are both sensors and effectors in communication among nervous, vascular, and immune systems. In the brain, they reside on the brain side of the blood brain barrier (BBB), and interact with neurons, glia, blood vessels, and other hematopoietic cells via their neuroactive prestored and newly synthesized chemicals. They are first responders, acting as catalysts and recruiters to initiate, amplify, and prolong other immune and nervous responses upon activation. MCs both promote deleterious outcomes in brain function and contribute to normative behavioral functioning, particularly cognition and emotionality. New experimental tools enabling isolation of brain MCs, manipulation of MCs or their products, and measurement of MC products in very small brain volumes present unprecedented opportunities for examining these enigmatic cells.
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