期刊
TRENDS IN NEUROSCIENCES
卷 36, 期 6, 页码 325-335出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2013.03.002
关键词
actin; amyloid-beta (A beta); dementia; frontotemporal dementia; synapse; TAU
资金
- National Institute on Aging (NIA)
- Ellison Medical Foundation
- Estate of Dr Clem Jones AO
- Australian Research Council (ARC)
- National Health and Medical Research Council (NHMRC)
Once perceived as solitary structures, mitochondria are now recognized as highly dynamic, interconnected organelles. The tight control of their fusion and fission, a process termed 'mitochondrial dynamics', is crucial for neurons, given their unique architecture and special energy and calcium-buffering requirements at the synapse. Interestingly, in Alzheimer's disease (AD), a condition initiated at the synapse, mitochondrial dynamics are severely impaired. Of the two proteins implicated in AD pathogenesis, amyloid-beta (A beta) and TAU, only the impact of A beta on mitochondrial dynamics has been studied in detail. We highlight recent findings that TAU exerts a determinative effect in the regulation of mitochondrial dynamics, and therefore neuronal function. In this process, the GTPase DRP1 has emerged as a key target of both A beta and TAU.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据