期刊
TRENDS IN NEUROSCIENCES
卷 36, 期 1, 页码 3-13出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2012.09.003
关键词
DNA methylation; learning and memory; behavioral adaptation; metaplasticity
资金
- National Health and Medical Research Council [APP1023127]
- Australian Research Council [DP1096148]
- National Sciences and Engineering Research Council of Canada
- University of Queensland
- Australian Research Council [DP1096148] Funding Source: Australian Research Council
DNA methylation was once considered to be a static epigenetic modification whose primary function was restricted to directing the development of cellular phenotype. However, it is now evident that the methylome is dynamically regulated across the lifespan: during development as a putative mechanism by which early experience leaves a lasting signature on the genome and during adulthood as a function of behavioral adaptation. Here, we propose that experience-dependent variations in DNA methylation, particularly within the context of learning and memory, represent a form of genomic metaplasticity that serves to prime the transcriptional response to later learning-related stimuli and neuronal reactivation.
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