期刊
TRENDS IN NEUROSCIENCES
卷 35, 期 12, 页码 752-761出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2012.09.001
关键词
microfluidic devices; neuronal polarity; developmental neuroscience; axon guidance; dendrite; synapse
资金
- National Institute of Mental Health [R21MH085220]
- National Heart, Lung and Blood Institute [RO1HL092571 Z ARRA, RO1HL086870]
- National Science Foundation (NSF) [IOS 0818555, STC CBET 0939511]
- National Institute of Child Health and Human Development Developmental Psychobiology and Neurobiology Training Grant [T32HD007333]
Understanding the signals that guide neuronal development and direct formation of axons, dendrites, and synapses during wiring of the brain is a fundamental challenge in developmental neuroscience. Discovery of how local signals shape developing neurons has been impeded by the inability of conventional culture methods to interrogate microenvironments of complex neuronal cytoarchitectures, where different subdomains encounter distinct chemical, physical, and fluidic features. Microfabrication techniques are facilitating the creation of microenvironments tailored to neuronal structures and subdomains with unprecedented access and control. The design, fabrication, and properties of microfluidic devices offer significant advantages for addressing unresolved issues of neuronal development. These high-resolution approaches are poised to contribute new insights into mechanisms for restoring neuronal function and connectivity compromised by injury, stress, and neurodegeneration.
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