期刊
TRENDS IN NEUROSCIENCES
卷 35, 期 5, 页码 305-314出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2012.01.002
关键词
RNA-Polymerase-1; rRNA; neuronal stress; nucleus; transcription; chromatin
资金
- National Institutes of Health [1R01NS073584, 1P30RR031159]
- National Science Foundation [IOS1021860]
- Commonwealth of Kentucky Challenge for Excellence
- Norton Healthcare
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1021860] Funding Source: National Science Foundation
Although, the nucleolus has been observed for almost 200 years in neurons, studies that directly address the neuronal roles of this subnuclear structure have appeared only recently. The aim of this review is to discuss recent progress and identify some critical questions that remain to be answered. As expected for the cellular center of ribosome biogenesis, the nucleolus is essential for the growth of developing neurons, including neurite morphogenesis and long-term maintenance of mature neurons. In addition, the nucleolus contributes to neuronal stress responses, including the regulation of apoptosis. Hence, disrupted neurodevelopment or neurodegeneration are among the likely consequences of nucleolar dysfunction. Conversely, the presence of active nucleoli may determine the potential for neurorepair.
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