期刊
TRENDS IN NEUROSCIENCES
卷 35, 期 12, 页码 715-722出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2012.09.002
关键词
vagus nerve stimulation; rehabilitation; neuropathology; sparse coding; neuromodulation; tinnitus
资金
- National Institute for Deafness and Other Communication Disorders [R01DC010433, R43DC010084, R44DC010084, R03DC004354, R15DC006624]
- Texas Advanced Research Program
- James S. McDonnell Foundation
A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies suggest that cortical map plasticity is typically a transient phase that improves learning by increasing the pool of task-relevant responses. Here, I discuss a new perspective on neural plasticity and suggest how plasticity might be targeted to reset dysfunctional circuits. Specifically, a new model is proposed in which map expansion provides a form of replication with variation that supports a Darwinian mechanism to select the most behaviorally useful circuits. Precisely targeted neural plasticity provides a new avenue for the treatment of neurological and psychiatric disorders and is a powerful tool to test the neural mechanisms of learning and memory.
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