期刊
TRENDS IN NEUROSCIENCES
卷 34, 期 6, 页码 283-292出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2011.03.005
关键词
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资金
- Australian Research Council [DP0343808, DP0877430]
- National Health and Medical Research Council [1003058]
- National Institutes of Health [R01 MH073700-01]
- Australian Research Council [DP0343808, DP0877430] Funding Source: Australian Research Council
Pavlovian fear conditioning depends on synaptic plasticity at amygdala neurons. Here, we review recent electrophysiological, molecular and behavioral evidence suggesting the existence of a distributed neural circuitry regulating amygdala synaptic plasticity during fear learning. This circuitry, which involves projections from the midbrain periaqueductal gray region, can be linked to prediction error and expectation modulation of fear learning, as described by associative and computational learning models. It controls whether, and how much, fear learning occurs by signaling aversive events when they are unexpected. Functional neuroimaging and clinical studies indicate that this prediction circuit is recruited in humans during fear learning and contributes to exposure-based treatments for clinical anxiety. This aversive prediction error circuit might represent a conserved mechanism for regulating fear learning in mammals.
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