期刊
TRENDS IN NEUROSCIENCES
卷 33, 期 9, 页码 391-398出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2010.06.003
关键词
-
资金
- National Institute on Drug Abuse [DA09621, DA015835, DA000453, DA029099]
- NATIONAL INSTITUTE ON DRUG ABUSE [K05DA029099, R37DA015835, K02DA000453, R01DA015835, R01DA009621] Funding Source: NIH RePORTER
Activation of medium spiny neurons (MSNs) of the nucleus accumbens is critical for goal-directed behaviors including cocaine seeking. Studies in cocaine-experienced rodents have revealed three major categories of neuroadaptations that influence the ability of glutamate inputs to activate MSNs: changes in synaptic AMPA receptor levels, changes in extracellular non-synaptic glutamate levels and changes in MSN intrinsic membrane excitability. Most studies have focused on one of these adaptations. This review will consider the possibility that they are causally related and speculate about how time-dependent changes in their interactions may regulate MSN output during early and late withdrawal from repeated cocaine exposure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据