期刊
TRENDS IN NEUROSCIENCES
卷 31, 期 7, 页码 371-376出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2008.05.001
关键词
-
资金
- NIA NIH HHS [P01 AG017628-01A1, P01 AG017628, P01 AG17628] Funding Source: Medline
- NINDS NIH HHS [K08 NS048914, K08 NS048914-01, K08 NS48914] Funding Source: Medline
The past 10 years have seen new approaches to elucidating genetic pathways regulating sleep. The emerging theme is that sleep-like states are conserved in evolution, with similar signaling pathways playing a role in animals as distantly related as flies and humans. We review the evidence for the presence of sleep states in non-mammalian species including zebrafish (Danio rerio), fruitflies (Drosophila melanogaster) and roundworms (Caenorhabditis elegans). We describe conserved sleep-regulatory molecular pathways with a focus on cAMP and epidermal growth factor signaling; neurotransmitters with conserved effects on sleep and wake regulation, including dopamine and GABA; and a conserved molecular response to sleep deprivation involving the chaperone protein BiP/GRP78.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据