期刊
TRENDS IN NEUROSCIENCES
卷 31, 期 12, 页码 626-636出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2008.09.002
关键词
-
资金
- INSERM
- Fondation pour la Recherche Medicale
- Federation pour la Recherche Sur le Cerveau
- l'Agence Nationale de la Recherche
During brain development cells divide, differentiate and migrate to their assigned targets to form synapses and active cell assemblies. This sequence is controlled both by genetic programs and environmental factors. Alterations of this sequence by mutations or environmental insults leads to the formation of misconnected circuits endowed with a 'pre-symptomatic signature'. I propose here that early- and late-onset neurological disorders as diverse as infantile epilepsies, mental retardation, dyslexia or, in certain conditions, even Huntington's and Alzheimer's disease might be, in part, born at early developmental stages before symptoms appear. The core of this working hypothesis is that imaging or non-invasive recordings might unravel signatures of disorders to come, thereby permitting earlier diagnosis and potential treatment of neurological disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据