期刊
TRENDS IN MOLECULAR MEDICINE
卷 20, 期 8, 页码 419-427出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2014.05.001
关键词
caloric restriction; cancer; chemotherapy; mTOR; AMPK; immune response
资金
- Fondation ARC (Association pour la Recherche sur le Cancer)
- Agence Nationale de la Recherche [ANR-09-JCJC-0003]
- Canceropole PACA
- Fondation de France
- Agence Nationale de la Recherche (ANR) [ANR-09-JCJC-0003] Funding Source: Agence Nationale de la Recherche (ANR)
Caloric restriction (CR) is currently the most robust environmental intervention known to increase healthy life and prolong lifespan in several models, from yeast to mice. Although the protective effect of CR on the incidence of cancer is well established, its impact on tumor cell responses to chemotherapeutic treatment is currently being investigated. Interestingly, the molecular mechanisms required to extend lifespan upon reduced food intake are being evaluated, and these mechanisms may offer new opportunities for therapeutic intervention. In addition, new findings suggest a beneficial effect of CR in enhancing the efficiency of tumor cell killing by chemotherapeutic drugs and inducing an anticancer immune response.
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