期刊
TRENDS IN MOLECULAR MEDICINE
卷 19, 期 10, 页码 625-632出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2013.07.006
关键词
CD69; inflammatory diseases; Treg lymphocytes; Th17 lymphocytes; immunoregulation
资金
- Spanish Ministry of Economy and Competitiveness [SAF2011-27330, SAF2011-25834]
- Instituto Salud Carlos III [RD12-0042-0056]
- Comunidad de Madrid [INDISNET 01592006]
- Ministry of Science and Innovation
- Pro CNIC Foundation
- [ERC-2011-AdG294340-GENTRIS]
Early studies described CD69 as a leukocyte activation marker, and suggested its involvement in the activation of different leukocyte subsets as well as in the pathogenesis of chronic inflammation. However, recent investigations have showed that CD69 knockout mice exhibit an enhanced or reduced susceptibility to different experimental models of inflammatory diseases, including those mediated by T helper 17 (Th17) lymphocytes. In this regard, the expression of CD69, both in Th17 lymphocytes and by a subset of regulatory T cells, has an important role in the control of the immune response and the inflammatory phenomenon. Therefore, different evidence indicates that CD69 exerts a complex immunoregulatory role in humans, and that it could be considered as a target molecule for the therapy of immune-mediated diseases.
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