期刊
TRENDS IN MOLECULAR MEDICINE
卷 19, 期 12, 页码 714-725出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2013.08.005
关键词
colorectal cancer; commensal bacteria; epigenetic regulation; inflammatory bowel disease; microbiota
资金
- National Institutes of Health (NIH) [1R01AI098833-01]
- Department of Defense (DoD) [CA111002]
- University of Florida
- NIH/National Center for Research Resources (NCRR) Clinical
- Translational Science Award to the University of Florida [UL1 RR 029890]
Mechanisms of colorectal cancer (CRC) development can be generally divided into three categories: genetic, epigenetic, and aberrant immunologic signaling pathways, all of which may be triggered by an imbalanced intestinal microbiota. Aberrant gut microbial composition, termed 'dysbiosis', has been reported in inflammatory bowel disease patients who are at increased risk for CRC development. Recent studies indicate that it is feasible to rescue experimental models of colonic cancer by oral treatment with genetically engineered beneficial bacteria and/or their immune-regulating gene products. Here, we review the mechanisms of epigenetic modulation implicated in the development and progression of CRC, which may be the result of dysbiosis, and therefore may be amenable to therapeutic intervention.
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