期刊
TRENDS IN MOLECULAR MEDICINE
卷 19, 期 9, 页码 513-514出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2013.07.008
关键词
Fanconi anemia; mitochondria; respiration; apoptosis; redox balance; carcinogenesis
Fanconi anemia (FA) is a rare, complex disorder that manifests in childhood. Children with FA suffer bone marrow failure, leukemias, or solid tumors. FA-associated mutations are found in 15 proteins that are involved in DNA repair. Some of these proteins have extranuclear activities involving redox balance, apoptosis, and energy metabolism; and recent data demonstrate respiratory impairment in FA cells, suggesting that altered mitochondrial function is a factor in this disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据