期刊
TRENDS IN MOLECULAR MEDICINE
卷 18, 期 4, 页码 224-232出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2012.02.001
关键词
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资金
- Japan Society for the Promotion of Science [22570131, B22390301]
- Ministry of Education, Culture, Sports, Science and Technology of Japan [21791483]
- Japan Science and Technology Agency (CREST)
- National Institutes of Health [P01CA71932, R01CA3000]
- Grants-in-Aid for Scientific Research [21791483, 23791737, 22570131] Funding Source: KAKEN
Despite the high prevalence of metastatic cancers and the poor outcome for patients, the processes of tumor metastasis still remain poorly understood. It has been shown that cell-surface carbohydrates attached to proteins through the amino acids serine or threonine (O-glycans) are involved in tumor metastasis, with the roles of O-glycans varying depending on their structure. Core2 O-glycans allow tumor cells to evade natural killer (NK) cells of the immune system and survive longer in the circulatory system, thereby promoting tumor metastasis. Core3 O-glycans or O-mannosyl glycans suppress tumor formation and metastasis by modulating integrin-mediated signaling. Here, we highlight recent advances in our understanding of the detailed molecular mechanisms by which O-glycans promote or suppress tumor metastasis.
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