期刊
TRENDS IN MOLECULAR MEDICINE
卷 17, 期 12, 页码 734-742出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2011.07.008
关键词
-
资金
- National Institute of Neurological Disorders and Stroke (NINDS) [NS045877, NS045021]
- Department of Defense CDMRP-TSC
The mTOR signaling network functions as a pivotal regulatory cascade during the development of the cerebral cortex. Aberrant hyperactivation of mTOR as a consequence of loss-of-function gene mutations encoding mTOR inhibitor proteins such as TSC1, TSC2, PTEN and STRAD alpha has been recently linked to developmental cortical malformations associated with epilepsy and neurobehavioral disabilities. Investigation of mTOR signaling in these disorders provides for the first time exciting future avenues for assessment of biomarkers, patient stratification and prognostic measures as well as the opportunity for targeted therapy to regulate mTOR activity across all age groups. As we learn more about mTOR and its activity in the developing brain, many challenges will arise that must be overcome before widespread clinical therapeutics can be implemented.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据