期刊
TRENDS IN MOLECULAR MEDICINE
卷 17, 期 7, 页码 372-379出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2011.02.003
关键词
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资金
- National Institutes of Health
- International Mental Health Research Organization
- Autism Speaks
Alterations in histone lysine methylation and other epigenetic regulators of gene expression contribute to changes in brain transcriptomes in mood and psychosis spectrum disorders, including depression and schizophrenia. Genetic association studies and animal models implicate multiple lysine methyltransferases and demethylases in the neurobiology of emotion and cognition. Here, we review the role of histone lysine methylation and transcriptional regulation in normal and diseased neurodevelopment and discuss various methyltransferases and demethylases as potential therapeutic targets in the treatment of neuropsychiatric disease.
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