期刊
TRENDS IN MOLECULAR MEDICINE
卷 16, 期 3, 页码 133-144出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2010.01.003
关键词
-
资金
- ARTP (Association pour la Recherche sur les Tumeurs de la Prostate)
- ARC (Association pour la Recherche sur le Cancer)
- Department of Veterans Affairs
- NCI [CA34590, CA116021, CA098807]
- NATIONAL CANCER INSTITUTE [R01CA116021, R01CA098807, R23CA034590, R01CA034590] Funding Source: NIH RePORTER
Chemokines are involved in cellular interactions and tropism in situations frequently associated with inflammation. Recently, the importance of chemokines and chemokine receptors in inflammation associated with carcinogenesis has been highlighted. Increasing evidence suggests that chemokines are produced by tumor cells as well as by cells of the tumor microenvironment including cancer-associated fibroblasts (CAFs), mesenchymal stem cells (MSCs), endothelial cells, tumor-associated macrophages (TAMs) and more recently tumor-associated neutrophils (TANs). In addition to affecting tumor cell proliferation, angiogenesis and metastasis, chemokines also seem to modulate senescence and cell survival. Here, we review recent progress on the roles of chemokines and chemokine receptors in cancer-related inflammation, and discuss the mechanisms underlying chemokine action in cancer that might facilitate the development of novel therapies in the future.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据