期刊
TRENDS IN MOLECULAR MEDICINE
卷 16, 期 5, 页码 230-237出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2010.03.004
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资金
- NIH [P01-CA67166, R01-CA118582]
- Magee-Womens Research Institute
- NATIONAL CANCER INSTITUTE [R37CA088480, R01CA118582, P01CA067166] Funding Source: NIH RePORTER
Hypoxia inducible factors (HIFs) regulate a variety of genes to prepare cells to adapt and survive under a hypoxic environment. Recently, microRNAs (miRNAs) have emerged as a new class of genes regulated by HIFs in response to hypoxia, of which miR-210 is the most consistently and predominantly upregulated miRNA. Functional studies have demonstrated that miR-210 is a versatile gene that regulates many aspects of hypoxia pathways, both in physiological and malignant conditions. Here, we summarize recent findings on the mechanism of hypoxia regulation of miR-210 expression and its multifaceted biological functions in normal physiological and malignant conditions, and discuss the challenges we face in elucidating the biological functions of miR-210 and exploring its potential use for therapeutics.
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