期刊
TRENDS IN MOLECULAR MEDICINE
卷 16, 期 1, 页码 1-6出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2009.11.002
关键词
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资金
- University of Liege (ULg)
- F N R S
- TELEVIE
- Belgian Federation against Cancer
- Belgian State, Science Policy Office [IAP6/18]
- Centre Anti-Cancereux
- Fonds Leon Frederieq
- Fondation Medicale Reine Elisabeth
- Agence Nationale pour la Recherche - Maladies Neurologiques et Psychiatriques
- Association pour la Recherche sur le Cancer (ARC, F S)
- Fondation pour la Recherche Medicale (FRM)
- Fondation BNP Paribas
- Federation pour la Recherche sur le Cerveau (FRC)
- CHDI, Inc Foundation
Neurological disorders are becoming a major public health issue in our aging society. An important objective is to understand the molecular events that underlie these diseases to prevent their onset and/or halt their progression. Acetylation of alpha-tubulin is a post-translational modification of microtubules that serves as a recognition signal for the anchoring of molecular motors and, as such, underlies the transport of various proteins or organelles in neurons. This process is affected in striatal and cortical neurons from Huntington's disease patients. Recent studies have shown that Elp3, the catalytic subunit of the Elongator complex, promotes the acetylation of a-tubulin in microtubules. Elongator complex activity is impaired in patients with familial dysautonomia. Based on converging experimental and clinical evidence, we propose that Elongator might be commonly targeted in different neurological disorders, and thus might represent a strong candidate for research and development efforts to design drug-based therapies.
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