期刊
TRENDS IN MOLECULAR MEDICINE
卷 16, 期 9, 页码 407-416出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2010.06.004
关键词
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资金
- Medical Research Council [G0600331] Funding Source: Medline
- MRC [G0600331] Funding Source: UKRI
The elucidation of several genetic etiologies of both monogenic and polygenic type 2 diabetes (T2D) has revealed several key regulators of glucose homeostasis and insulin secretion in humans. Genome-wide association studies (GWAS) have been instrumental in most of these recent discoveries. The T2D susceptibility genes identified so far are mainly involved in pancreatic p-cell maturation or function. However, common DNA variants in those genes only explain similar to 10% of T2D heritability. The resequencing of whole exomes and whole genomes with next-generation technologies should identify additional genetic changes that contribute to the monogenic forms of diabetes and possibly provide novel clues to the genetic architecture of common adult T2D.
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