期刊
TRENDS IN MOLECULAR MEDICINE
卷 15, 期 3, 页码 120-128出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2009.01.005
关键词
-
资金
- NCI NIH HHS [P50 CA098258, P30 CA016672] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA016672, P50CA098258] Funding Source: NIH RePORTER
Uniparental disomy (UPD) results when both copies of a chromosome pair originate from one parent. In humans, this might result in developmental disease or cancer due to either the production of homozygosity (caused by mutated or methylated genes or by microRNA sequences) or an aberrant pattern of imprinting. Constitutional UPD is associated with meiotic errors, resulting in developmental diseases, whereas acquired UPD probably occurs as a result of a mitotic error in somatic cells, which can be an important step in cancer development and progression. This review summarizes the mechanisms underlying UPD and their emerging association with cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据