期刊
TRENDS IN MOLECULAR MEDICINE
卷 14, 期 4, 页码 152-160出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2008.02.001
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资金
- NCI NIH HHS [P01 CA50661] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P01CA050661] Funding Source: NIH RePORTER
Reversible protein phosphorylation plays a central role in regulating intracellular signaling. Dysregulation of the mechanisms that regulate phosphorylation plays a direct role in cancer initiation and maintenance. Although abundant evidence supports the role of kinase oncogenes in cancer development, recent work has illuminated the role of specific protein phosphatases in malignant transformation. Protein phosphatase 2A (PP2A) is the major serine-threonine phosphatase in mammalian cells. Inactivation of PP2A by viral oncoproteins, mutation of specific subunits or overexpression of endogenous inhibitors contributes to cell transformation by regulating specific phosphorylation events. Here, we review recent progress in our understanding of how PP2A regulates mitogenic signaling pathways in cancer pathogenesis and how PP2A activity is modulated in human cancers.
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