期刊
TRENDS IN MOLECULAR MEDICINE
卷 14, 期 1, 页码 37-44出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2007.11.004
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资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL080187, R01HL070274, R01HL052233] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK062729] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS010828] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL070274-04, R01 HL070274-05, R01 HL052233-12, R01 HL052233-10, R01 HL052233-11, R01 HL080187-02, R01 HL070274, R01 HL080187-03, R01 HL080187, R01 HL080187-01A1, R01 HL052233] Funding Source: Medline
- NIDDK NIH HHS [R01 DK062729, R01 DK062729-05] Funding Source: Medline
- NINDS NIH HHS [P01 NS010828, P01 NS010828-330036] Funding Source: Medline
Statins inhibit the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which is required for cholesterol biosynthesis, and are beneficial in the primary and secondary prevention of cardiovascular disease. Most of the benefits of statin therapy are owing to the lowering of serum cholesterol levels. However, by inhibiting HMG-CoA reductase, statins can also inhibit the synthesis of isoprenoids, which are important lipid attachments for intracellular signaling molecules, such as Rho, Rac and Cdc42. Therefore, it is possible that statins might exert chollesterol-independent or 'pleiotropic' effects through direct inhibition of these small GTP-binding proteins. Recent studies have shown that statins might have important roles in diseases that are not mediated by cholesterol. Here, we review data from recent clinical trials that support the concept of statin pleiotropy and provide a rationale for their clinical importance.
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