期刊
TRENDS IN MOLECULAR MEDICINE
卷 14, 期 11, 页码 495-502出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2008.09.003
关键词
-
资金
- National Institutes of Health [HL-38901, NS-24621, HL-62984]
- American Heart Association [0575092N, 0725643Z]
- National Health and Medical Research Council of Australia [359282]
The study of reactive oxygen species (ROS) and oxidative stress remains a very active area of biological research, particularly in relation to cellular signaling and the role of ROS in disease. In the cerebral circulation, oxidative stress occurs in diverse forms of disease and with aging. Within the vessel wall, ROS produce complex structural and functional changes that have broad implications for regulation of cerebral perfusion and permeability of the blood-brain barrier. These oxidative-stress-induced changes are thought to contribute to the progression of cerebrovascular disease. Here, we highlight recent findings in relation to oxidative stress in the cerebral vasculature, with an emphasis on the emerging role for NADPH oxidases as a source of ROS and the role of ROS in models of disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据