期刊
TRENDS IN MICROBIOLOGY
卷 26, 期 12, 页码 978-985出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2018.06.007
关键词
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资金
- European Research Council under the European Union's Horizon 2020 research and Innovation programme (ERC) [757440-PLASREVOLUTION]
Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply increase mortality risk in critically ill patients. The horizontal spread of antibiotic resistance genes among bacteria is driven by bacterial plasmids, promoting the evolution of resistance. Crucially, particular associations exist between resistance plasmids and bacterial clones that become especially successful in clinical settings. However, the factors underlying the success of these associations remain unknown. Recent in vitro evidence reveals (i) that plasmids produce fitness costs in bacteria, and (ii) that these costs are alleviated over time through compensatory mutations. I argue that plasmid-imposed costs and subsequent compensatory adaptation may determine the success of associations between plasmids and bacteria in clinical settings, shaping the in vivo evolution of antibiotic resistance.
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