期刊
TRENDS IN MICROBIOLOGY
卷 22, 期 1, 页码 21-27出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.10.004
关键词
pore-forming toxins; toxin receptors; membrane proteins; Staphylococcus aureus
资金
- American Heart Association Scientist Development [09SDG2060036]
- National Institutes of Health [R56 AI091856, R01 AI099394]
- New York University School of Medicine Development Funds
- National Institutes of Health Training Grant [5T32 AI007180]
Staphylococcus aureus employs numerous pore-forming cytotoxins to injure host immune cells and promote infection. Until recently, it was unclear how these cytotoxins targeted specific cell types for lysis. Membrane lipids were initially postulated to be cytotoxin receptor candidates. However, the cell-type specificity and species-dependent targeting of these toxins did not support lipids as sole receptors. The recent identification of proteinaceous receptors for several S. aureus cytotoxins now provides an explanation for the observed tropism. These findings also have important implications for the implementation of animal models to study S. aureus pathogenesis, and for the development of novel therapeutics.
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