期刊
TRENDS IN MICROBIOLOGY
卷 22, 期 4, 页码 183-191出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.01.010
关键词
bat-derived influenza-like virus; hemagglutinin (HA); neuraminidase (NA); PA; reassortment; H17N10; H18N11
资金
- 973 Project of Ministry of Science and Technology of China (MOST) [2011CB504703]
- Key Project of the National Natural Science Foundation of China (NSFC) [81330082]
- NSFC Innovative Research Group [81321063]
Shorebirds and waterfowls are believed to be the reservoir hosts for influenza viruses, whereas swine putatively act as mixing vessels. The recent identification of two influenza-like virus genomes (designated H17N10 and H18N11) from bats has challenged this notion. A crucial question concerns the role bats might play in influenza virus ecology. Structural and functional studies of the two major surface envelope proteins, hemagglutinin (HA) and neuraminidase (NA), demonstrate that neither has canonical HA or NA functions found in influenza viruses. However, putative functional modules and domains in other encoded proteins are conserved, and the N-terminal domain of the H17N10 polymerase subunit PA has a classical structure and function. Therefore, potential genomic reassortments of such influenza-like viruses with canonical influenza viruses cannot be excluded at this point and should be assessed.
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