期刊
TRENDS IN MICROBIOLOGY
卷 22, 期 1, 页码 7-13出版社
CELL PRESS
DOI: 10.1016/j.tim.2013.10.006
关键词
Streptococcus pyogenes; virulence; evolution; regulation; epigenetic; bistability
资金
- Swedish Research Council [K2011-56X-07480, 2011-5680]
- Knut and Alice Wallenberg Foundation [KAW 2011.0037]
Group A streptococci (GAS) cause three different types of infection (sensu lato) with distinct levels of virulence: asymptomatic colonization, superficial symptomatic infection, and invasive infection. To address why this pattern with several infection types has evolved, we combine mechanistic understanding from infection medicine with recent theory from evolutionary ecology. We propose that asymptomatic colonization and superficial symptomatic infection exploit different states of the host epithelium to maximize transmission between hosts in different epidemiological conditions, whereas the ability of the bacteria to cause invasive infection is a non-adaptive side effect of traits required for superficial symptomatic infection.
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