期刊
TRENDS IN MICROBIOLOGY
卷 22, 期 8, 页码 438-445出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.04.007
关键词
chromosome structure; fitness
资金
- BBSRC [BB/G012016/1] Funding Source: UKRI
- MRC [G0501415] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G012016/1] Funding Source: Medline
- Medical Research Council [G0501415] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/G012016/1] Funding Source: researchfish
- Medical Research Council [G0501415] Funding Source: researchfish
Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly used to treat a range of infections. Resistance to these agents is multifactorial and can be via one or a combination of target-site gene mutations, increased production of multidrug-resistance (MDR) efflux pumps, modifying enzymes, and/or target-protection proteins. Fluoroquinolone-resistant clinical isolates of bacteria have emerged readily and recent data have shown that resistance to this class of antibiotics can have diverse, species-dependent impacts on host-strain fitness. Here we outline the impacts of quinolone-resistance mutations in relation to the fitness and evolutionary success of mutant strains.
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