期刊
TRENDS IN MICROBIOLOGY
卷 22, 期 8, 页码 446-455出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.04.001
关键词
influenza A virus; packaging; RNA-RNA interactions; supramolecular complex; genetic reassortment
资金
- Centre National de la Recherche Scientifique
- VirNext
Influenza A viruses package their segmented RNA genome in a selective manner. Electron tomography, biochemical assays, and replication assays of viruses produced by reverse genetics recently unveiled molecular details of this mechanism, whereby different influenza viral strains form different and unique networks of direct intermolecular RNA-RNA interactions. Together with detailed views of the three-dimensional structure of the viral ribonucleoparticles, these recent advances help us understand the rules that govern genome packaging. They also have deep implications for the genetic reassortment processes, which are responsible for devastating pandemics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据