期刊
TRENDS IN MICROBIOLOGY
卷 22, 期 11, 页码 614-622出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2014.07.001
关键词
metabolic adaptation; stress adaptation; cell wall; virulence factors; regulatory networks; fungal immunology
资金
- Welcome Trust Strategic Award in Medical Mycology and Fungal Immunology [097377]
- Wellcome Trust [080088, 086558, 101873]
- European Commission (STRIFE) [ERC-2009-AdG-249793, ERC-2012-StG-310372]
- UK Biotechnology and Biological Sciences Research Council [BB/F00513X/1, BB/K017365/1]
- BBSRC [BB/K017365/1, BB/F00513X/1, BB/F010826/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F010826/1, BB/F00513X/1, BB/K017365/1, BBS/B/06679] Funding Source: researchfish
Metabolism is integral to the pathogenicity of Candida albicans, a major fungal pathogen of humans. As well as providing the platform for nutrient assimilation and growth in diverse host niches, metabolic adaptation affects the susceptibility of C. albicans to host-imposed stresses and antifungal drugs, the expression of key virulence factors, and fungal vulnerability to innate immune defences. These effects, which are driven by complex regulatory networks linking metabolism, morphogenesis, stress adaptation, and cell wall remodelling, influence commensalism and infection. Therefore, current concepts of Candida-host interactions must be extended to include the impact of metabolic adaptation upon pathogenicity and immunogenicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据