期刊
TRENDS IN MICROBIOLOGY
卷 21, 期 11, 页码 568-574出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.08.006
关键词
respiratory syncytial virus; pathogen recognition receptors; innate immunity; pathogenesis
资金
- Canadian Institutes of Health Research (CIHR) Team Grant in Mutagenesis and Infectious Diseases
- CIHR
Human respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection in young children, immunocompromised adults, and the elderly. The innate immune response plays a pivotal role in host defense against RSV, but whether severe outcomes following RSV infection result from excessive or poor innate immune recognition remains unclear. Recent research suggests a situation in which crosstalk between families of pattern recognition receptors (PRRs) occurs in a cell type-dependent manner. The current challenge to empower novel therapeutic approaches and vaccine development is to confirm the role of the individual receptors in RSV pathogenesis in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据