期刊
TRENDS IN MICROBIOLOGY
卷 21, 期 2, 页码 63-72出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2012.10.001
关键词
synthase; exopolysaccharide; alginate; cellulose; poly-beta-D-N-acetylglucosamine
资金
- Canadian Institutes of Health Research (CIHR) [13337, 43998]
- Natural Science and Engineering Research Council of Canada (NSERC)
- Cystic Fibrosis Canada
- Ontario Graduate Scholarship Program
- Ontario Student Opportunities Trust Fund
- Hospital for Sick Children Foundation Student Scholarship Program
The biosynthesis and export of bacterial cell-surface polysaccharides is known to occur through several distinct mechanisms. Recent advances in the biochemistry and structural biology of several proteins in synthase-dependent polysaccharide secretion systems have identified key conserved components of this pathway in Gram-negative bacteria. These components include an inner-membrane-embedded polysaccharide synthase, a periplasmic tetratricopeptide repeat (TPR)-containing scaffold protein, and an outer-membrane beta-barrel porin. There is also increasing evidence that many synthase-dependent systems are post-translationally regulated by the bacterial second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP). Here, we compare these core proteins in the context of the alginate, cellulose, and poly-beta-D-N-acetylglucosamine (PNAG) secretion systems.
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