期刊
TRENDS IN MICROBIOLOGY
卷 21, 期 5, 页码 238-244出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.02.004
关键词
respiratory syncytial virus; human airway epithelium; cytopathogenesis; well-differentiated primary airway epithelium cultures
资金
- Public Health Agency HSC Research & Development Division, Northern Ireland
- European Social Fund
- Royal Belfast Hospital for Sick Children
- Invest NI
- Public Health Agency [RRG/3244/05] Funding Source: researchfish
Although respiratory syncytial virus (RSV) is a major human respiratory pathogen, our knowledge of how it causes disease in humans is limited. Airway epithelial cells are the primary targets of RSV infection in vivo, so the generation and exploitation of RSV infection models based on morphologically and physiologically authentic well-differentiated primary human airway epithelial cells cultured at an air-liquid interface (WD-PAECs) provide timely developments that will help to bridge this gap. Here we review the interaction of RSV with WD-PAEC cultures, the authenticity of the RSV-WD-PAEC models relative to RSV infection of human airway epithelium in vivo, and future directions for their exploitation in our quest to understand RSV pathogenesis in humans.
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