期刊
TRENDS IN MICROBIOLOGY
卷 21, 期 6, 页码 286-295出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.03.005
关键词
herpesvirus; protein kinase; phosphorylation; protein kinase inhibitor; antiviral drug development
资金
- National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) award [R21AI101377]
Herpesviruses are ubiquitous human pathogens that establish lifelong persistent infections. Clinical manifestations range from mild self-limiting outbreaks such as childhood rashes and cold sores to the more severe and life-threatening outcomes of disseminated infection, encephalitis, and cancer. Nucleoside analog drugs that target viral DNA replication provide the primary means of treatment. However, extended use of these drugs can result in selection for drug-resistant strains, particularly in immunocompromised patients. In this review we will present recent observations about the participation of cellular protein kinases in herpesvirus biology and discuss the potential for targeting these protein kinases as well as the herpesvirus-encoded protein kinases as an anti-herpesvirus therapeutic strategy.
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