期刊
TRENDS IN MICROBIOLOGY
卷 21, 期 7, 页码 342-349出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.04.005
关键词
host inflammasome activation; caspase-1; pathogens; bacterial evasion
资金
- Grants-in-Aid for Scientific Research [24659201, 23390106] Funding Source: KAKEN
The inflammasome is composed of nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins, and leads to caspase-1 activation and subsequent secretion of the proinflammatory cytokines interleukin 113 (IL-1 beta) and interleukin-18 (IL-18). After certain pathogenic bacteria infect host cells, such as macrophages, NLR-mediated inflammasome activation is triggered to form part of the host defenses against the invading pathogens. However, recent evidence has shown that bacteria have strategies for evading inflammasome activation in host cells. In this review, we focus on NLR-mediated inflammasome activation and bacterial evasion of the inflammasome as part of the battle between the host defenses and pathogens.
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