期刊
TRENDS IN MICROBIOLOGY
卷 20, 期 12, 页码 577-585出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2012.08.009
关键词
antibiotic tolerance; toxin-antitoxin modules; noise; heterogeneity; chronic infections; cancer
资金
- Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen)
- KU Leuven Research Council [IDO/07/010, IDO/09/010]
- Fund for Scientific Research - Flanders (FWO) [G.0299.07, G.0413.10, G.0471.12]
Persister cells display tolerance to high doses of bactericidal antibiotics and typically comprise a small fraction of a bacterial population. Recently, evidence was provided for a causal link between therapy failure and the presence of persister cells in chronic infections, underscoring the need for research on bacterial persistence. A series of recent breakthroughs have shed light on the multiplicity of persister genes, the contribution of gene expression noise to persister formation, the importance of active responses to antibiotic tolerance and heterogeneity among persister cells. Moreover, the development of in vivo model systems has highlighted the clinical relevance of persistence. This review discusses these recent advances and how this knowledge fundamentally changes the way in which we will perceive the problem of antibiotic tolerance in years to come.
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