期刊
TRENDS IN MICROBIOLOGY
卷 20, 期 10, 页码 477-484出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2012.07.001
关键词
mycobacteria; tuberculosis; ESX; type VII secretion; virulence; granuloma formation
资金
- Smart Mix program of The Netherlands Ministry of Economic Affairs
- The Netherlands Ministry of Education, Culture, and Science
Mycobacteria, such as the major human pathogen Mycobacterium tuberculosis, have a highly unusual and characteristic diderm cell envelope that protects them against harmful conditions. Protein secretion across this hydrophobic barrier requires specialized secretion systems. Recently, a type VII secretion (T7S) pathway has been identified that fulfills this function. Pathogenic mycobacteria have up to five different T7S systems, some of which play a crucial role in virulence. The interactions between secreted substrates and host molecules are only starting to become clear and will help in furthering our understanding of the persistence of these enigmatic pathogens. In this review, we discuss current knowledge on the role of T7S systems in mycobacterial virulence.
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