期刊
TRENDS IN MICROBIOLOGY
卷 19, 期 1, 页码 33-39出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2010.10.002
关键词
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资金
- National Cancer Institute
- NATIONAL CANCER INSTITUTE [R01CA059655, R01CA142861, R37CA074202] Funding Source: NIH RePORTER
Human papillomaviruses (HPVs) are the etiologic agents of cervical and other epithelial cancers. Persistence of infections by high-risk HPV types is the single greatest risk factor for malignant progression. Although prophylactic vaccines have been developed that target high-risk HPV types, there is a continuing need to understand better the virus-host interactions that underlie persistent benign infection and progression to cancer. In this review we summarize the molecular events that facilitate the differentiation-dependent HPV life cycle, how the life cycle is organized to facilitate virus persistence, and how the activities of HPV regulatory proteins result in malignancy.
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