期刊
TRENDS IN MICROBIOLOGY
卷 19, 期 7, 页码 307-314出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2011.03.008
关键词
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资金
- NIH [AI064768, AI63446, AI081094]
- Milstein Program in Chemical Biology of Infectious Disease
- Bill and Melinda Gates Foundation
- Burroughs Wellcome Career Award
- William Randolph Hearst Foundation
Recent advances in liquid chromatography and mass spectrometry have enabled the highly parallel, quantitative measurement of metabolites within a cell and the ability to trace their biochemical fates. In Mycobacterium tuberculosis (Mtb), these advances have highlighted major gaps in our understanding of central carbon metabolism (CCM) that have prompted fresh interpretations of the composition and structure of its metabolic pathways and the phenotypes of Mtb strains in which CCM genes have been deleted. High-throughput screens have demonstrated that small chemical compounds can selectively inhibit some enzymes of Mtb's CCM while sparing homologs in the host. Mtb's CCM has thus emerged as a frontier for both fundamental and translational research.
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