期刊
TRENDS IN MICROBIOLOGY
卷 18, 期 1, 页码 11-19出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2009.11.003
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资金
- Intramural NIH HHS [ZIA LM000073-16] Funding Source: Medline
- NATIONAL LIBRARY OF MEDICINE [ZIALM000073] Funding Source: NIH RePORTER
Metagenomic analysis of viruses suggests novel patterns of evolution, changes the existing ideas of the composition of the virus world and reveals novel groups of viruses and virus-like agents. The gene composition of the marine DNA virome is dramatically different from that of known bacteriophages. The virome is dominated by rare genes, many of which might be contained within virus-like entities such as gene transfer agents. Analysis of marine metagenomes thought to consist mostly of bacterial genes revealed a variety of sequences homologous to conserved genes of eukaryotic nucleocytoplasmic large DNA viruses, resulting in the discovery of diverse members of previously undersampled groups and suggesting the existence of new classes of virus-like agents. Unexpectedly, metagenomics of marine RNA viruses showed that representatives of only one superfamily of eukaryotic viruses, the picorna-like viruses, dominate the RNA virome.
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